Severe acute liver failure as the initial manifestation of haematological malignancy

Eur J Gastroenterol Hepatol. 1997 Nov;9(11):1113-5. doi: 10.1097/00042737-199711000-00016.

Abstract

Acute liver failure is rarely secondary to lymphoma or leukaemia and it is extremely uncommon as the initial presentation of malignancy. We report a case of a young adult patient with severe acute liver failure referred for liver transplant, in which a Burkitt acute lymphoblastic leukaemia was diagnosed by bone marrow examination. A complete recovery and long remission were obtained with chemotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow / pathology
  • Burkitt Lymphoma / diagnosis*
  • Burkitt Lymphoma / drug therapy
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Hepatomegaly / diagnostic imaging
  • Hepatomegaly / drug therapy
  • Humans
  • Liver Failure, Acute / diagnosis*
  • Liver Failure, Acute / drug therapy
  • Methotrexate / administration & dosage
  • Prednisone / administration & dosage
  • Tomography, X-Ray Computed
  • Ultrasonography
  • Vincristine / administration & dosage

Substances

  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone
  • Methotrexate

Supplementary concepts

  • COP protocol 2