Abstract
The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture of the antigen-binding regions of TCRs and antibodies, and how the TCR interacts with pMHC ligands as well as with superantigens.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Bacterial / chemistry*
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Antigens, Bacterial / immunology
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Antigens, Bacterial / metabolism
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Binding Sites
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Crystallography, X-Ray
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Histocompatibility Antigens / chemistry*
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Histocompatibility Antigens / immunology
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Histocompatibility Antigens / metabolism
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Humans
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Models, Molecular
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Protein Structure, Tertiary
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Receptors, Antigen, T-Cell / chemistry*
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism
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Superantigens / chemistry*
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Superantigens / immunology
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Superantigens / metabolism
Substances
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Antigens, Bacterial
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Histocompatibility Antigens
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Receptors, Antigen, T-Cell
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Superantigens