Hepatitis C virus genotypes implicated in mixed cryoglobulinemia

J Med Virol. 1998 Jan;54(1):20-5. doi: 10.1002/(sici)1096-9071(199801)54:1<20::aid-jmv4>3.0.co;2-r.

Abstract

Recent reports suggest that hepatitis C virus (HCV) might be a causative agent of mixed cryoglobulinemia. To determine whether the HCV genotype is a factor implicated in the onset of cryoglobulinemia, genotyping by direct sequencing of polymerase chain reaction products of the 5' non coding region was carried out among 45 HCV-infected patients. Genotypes 1 and 2 were found more prevalent in symptomatic cryoglobulinemia patients. Due to the presence of genotypes 4 and 5 found in this panel of French patients (9.3%), HCV genotyping based on sequence determination is recommended.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cryoglobulinemia / virology*
  • Female
  • Genotype
  • Hepacivirus / genetics*
  • Humans
  • Male
  • Middle Aged
  • Phylogeny
  • Polymerase Chain Reaction
  • RNA, Viral / genetics
  • Transcription, Genetic

Substances

  • RNA, Viral

Associated data

  • GENBANK/U51746
  • GENBANK/U51747
  • GENBANK/U51748
  • GENBANK/U51749
  • GENBANK/U51750
  • GENBANK/U51751
  • GENBANK/U51752
  • GENBANK/U51753
  • GENBANK/U51754
  • GENBANK/U51755
  • GENBANK/U51756
  • GENBANK/U51757
  • GENBANK/U51758
  • GENBANK/U51759
  • GENBANK/U51760
  • GENBANK/U51761
  • GENBANK/U51762
  • GENBANK/U51763
  • GENBANK/U51764
  • GENBANK/U51765
  • GENBANK/U51766
  • GENBANK/U51767
  • GENBANK/U51768
  • GENBANK/U51769
  • GENBANK/U51770
  • GENBANK/U51771
  • GENBANK/U51772
  • GENBANK/U51773
  • GENBANK/U51774
  • GENBANK/U51775