Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses

J Virol. 1998 Feb;72(2):1652-6. doi: 10.1128/JVI.72.2.1652-1656.1998.

Abstract

The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • HIV-1 / physiology*
  • Humans
  • Mice
  • Receptors, CCR4
  • Receptors, Chemokine / physiology*
  • Receptors, Virus / physiology*
  • T-Lymphocytes / virology*
  • Virus Replication

Substances

  • CCR4 protein, human
  • Ccr4 protein, mouse
  • Receptors, CCR4
  • Receptors, Chemokine
  • Receptors, Virus