Beta-blockers in heart failure--a cardioprotective therapy?

M J Landray; M J Kendall

doi:10.1046/j.1365-2710.1997.9775097.x

Beta-blockers in heart failure--a cardioprotective therapy?

J Clin Pharm Ther. 1997 Jun;22(3):181-5. doi: 10.1046/j.1365-2710.1997.9775097.x.

Authors

M J Landray¹, M J Kendall

Affiliation

¹ Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, U.K.

PMID: 9447472
DOI: 10.1046/j.1365-2710.1997.9775097.x

Abstract

Heart failure remains a major cause of morbidity and mortality despite optimum treatment with angiotensin-converting enzyme inhibitors and diuretics. Meta-analysis of recent placebo-controlled, randomized trials suggest that treatment with beta-blockers may significantly reduce mortality by 35%.

Publication types

Comparative Study
Meta-Analysis

MeSH terms

Adrenergic beta-Antagonists / administration & dosage
Adrenergic beta-Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / administration & dosage
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / drug effects
Down-Regulation
Follow-Up Studies
Heart Failure / drug therapy*
Heart Rate / drug effects
Humans
Myocardial Contraction / drug effects
Randomized Controlled Trials as Topic

Substances

Adrenergic beta-Antagonists
Angiotensin-Converting Enzyme Inhibitors