Abstract
The in vitro anti-tumor promoting effect of hypocotyls from fresh soybeans was evaluated. The dimethyl sulfoxide extracts of hypocotyls showed a stronger inhibitory effect than that of soybeans on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate. Daidzin, an isoflavone with the highest content of hypocotyls, was also inhibitory. An in vivo evaluation of anti-tumor promoting activity of hypocotyls against the skin of mice also revealed a significant inhibitory effect on tumor formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Viral / metabolism*
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Burkitt Lymphoma / metabolism
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Enzyme Inhibitors / pharmacology
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Female
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Glycine max / chemistry
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Glycine max / physiology*
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Hypocotyl / physiology*
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Isoflavones / analysis
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Isoflavones / isolation & purification
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Isoflavones / pharmacology
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Mice
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Mice, Inbred ICR
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Skin Neoplasms / chemically induced
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Skin Neoplasms / prevention & control*
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Tetradecanoylphorbol Acetate
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Tumor Cells, Cultured
Substances
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Antigens, Viral
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Enzyme Inhibitors
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Epstein-Barr virus early antigen
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Isoflavones
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daidzin
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Tetradecanoylphorbol Acetate