Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies

J Med Chem. 1998 Jan 29;41(3):271-5. doi: 10.1021/jm970762d.

Authors

K S Atwal¹, G J Grover, N J Lodge, D E Normandin, S C Traeger, P G Sleph, R B Cohen, C C Bryson, K E Dickinson

Affiliation

¹ Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA.

PMID: 9464357
DOI: 10.1021/jm970762d

No abstract available

MeSH terms

ATP-Binding Cassette Transporters
Animals
Cardiotonic Agents / chemistry
Cardiotonic Agents / pharmacology*
Dogs
KATP Channels
Muscle Relaxation / drug effects
Muscle, Smooth / drug effects
Muscle, Smooth / physiology
Myocardium / metabolism*
Potassium Channels / agonists*
Potassium Channels / metabolism
Potassium Channels, Inwardly Rectifying
Protein Binding
Structure-Activity Relationship

Substances

ATP-Binding Cassette Transporters
Cardiotonic Agents
KATP Channels
Potassium Channels
Potassium Channels, Inwardly Rectifying
uK-ATP-1 potassium channel