Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden)

M Pohl; L B Zimmerhackl; F Heinen; A H Sutor; R Schneppenheim; M Brandis

doi:10.1016/s0022-3476(98)70504-9

Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden)

J Pediatr. 1998 Jan;132(1):159-61. doi: 10.1016/s0022-3476(98)70504-9.

Authors

M Pohl¹, L B Zimmerhackl, F Heinen, A H Sutor, R Schneppenheim, M Brandis

Affiliation

¹ University Children's Hospital, Albert-Ludwig University, Freiburg, Germany.

PMID: 9470020
DOI: 10.1016/s0022-3476(98)70504-9

Abstract

Bilateral renal vein thrombosis and venous sinus thrombosis were diagnosed within 3 weeks of birth in a full-term neonate. Heterozygosity for a factor V mutation leading to resistance against the anticoagulatory properties of activated protein C was found. Heparin therapy led to resolution of the thrombotic manifestations. With long-term oral anticoagulation, no relapse or other thrombotic event occurred during infancy.

Publication types

Case Reports

MeSH terms

Anticoagulants / therapeutic use
Blood Coagulation Disorders / complications
Blood Coagulation Disorders / drug therapy
Blood Coagulation Disorders / genetics*
Factor V* / genetics*
Heparin / therapeutic use
Heterozygote
Humans
Infant, Newborn
Intracranial Embolism and Thrombosis / complications
Intracranial Embolism and Thrombosis / drug therapy
Intracranial Embolism and Thrombosis / genetics*
Male
Mutation*
Renal Veins*
Thrombosis / complications
Thrombosis / drug therapy
Thrombosis / genetics*

Substances

Anticoagulants
factor V Leiden
Factor V
Heparin