Vertical transmission of hepatitis C virus infection: usefulness of viremia detection in HIV-seronegative hepatitis C virus-seropositive mothers

R Giacchino; L Tasso; A Timitilli; E Castagnola; E Cristina; N Sinelli; C Gotta; G Giambartolomei; P Moscatelli; A Picciotto

doi:10.1016/s0022-3476(98)70507-4

Vertical transmission of hepatitis C virus infection: usefulness of viremia detection in HIV-seronegative hepatitis C virus-seropositive mothers

J Pediatr. 1998 Jan;132(1):167-9. doi: 10.1016/s0022-3476(98)70507-4.

Authors

R Giacchino¹, L Tasso, A Timitilli, E Castagnola, E Cristina, N Sinelli, C Gotta, G Giambartolomei, P Moscatelli, A Picciotto

Affiliation

¹ Department of Infectious Diseases G. Gaslini Children's Hospital, Genoa, Italy.

PMID: 9470023
DOI: 10.1016/s0022-3476(98)70507-4

Abstract

Seventy mother-newborn pairs were studied for hepatitis C viremia to evaluate the risk of vertical transmission of hepatitis C virus from human immunodeficiency virus-negative mothers. Forty-five mothers were hepatitis C virus-RNA positive: 4 to 45 children were positive at birth and during follow-up. The level of viremia plays an important role in vertical transmission.

MeSH terms

Female
HIV Seronegativity
Hepacivirus / isolation & purification*
Hepatitis C / congenital*
Hepatitis C / diagnosis
Hepatitis C / transmission*
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pregnancy
Pregnancy Complications, Infectious / virology*
RNA, Viral / blood
Viremia / diagnosis

Substances

RNA, Viral