Abstract
Case report:
We report a typical complication of hepatic artery infusion therapy (HAI) in a patient with colon cancer metastatic to the liver. One year after the last HAI-therapy the patient presented with upper gastrointestinal bleeding. Endoscopy showed a large duodenic ulcer penetrating into an adjacent hepatic colon cancer metastasis. The hepatic artery catheter was visible at the ground of the duodenic ulcer.
Conclusion:
Thirty-five percent of patients under HAI-therapy develop gastric/duodenic ulcers. The severity of the HAI complication presented here, however, is quite uncommon.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Adenocarcinoma / drug therapy
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Adenocarcinoma / secondary*
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Aged
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Catheters, Indwelling*
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Duodenal Ulcer / chemically induced*
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Duodenal Ulcer / pathology
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Duodenum / drug effects
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Duodenum / pathology
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Endoscopy, Gastrointestinal
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Fluorouracil / administration & dosage
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Fluorouracil / adverse effects*
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Humans
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Infusions, Intra-Arterial / instrumentation*
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Intestinal Mucosa / drug effects
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Intestinal Mucosa / pathology
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Leucovorin / administration & dosage
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Leucovorin / adverse effects*
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Liver Neoplasms / drug therapy
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Liver Neoplasms / secondary*
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Male
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Peptic Ulcer Perforation / chemically induced*
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Peptic Ulcer Perforation / pathology
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Sigmoid Neoplasms / drug therapy*