Abstract
Specific causes for Lhermitte's sign (LS) in cancer patients are spinal cord compression, radiation therapy to the spinal cord, and cisplatin chemotherapy. We observed a transient LS in five of 87 patients treated with more than two cycles of 100 mg/m2 docetaxel (Taxotere). LS developed either concurrently or after the onset of docetaxel-induced sensory neuropathy, and disappeared after the discontinuation or dose reduction of chemotherapy.
Publication types
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Case Reports
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Clinical Trial
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Clinical Trial, Phase II
MeSH terms
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Adult
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Antineoplastic Agents, Phytogenic / administration & dosage
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Antineoplastic Agents, Phytogenic / adverse effects*
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Docetaxel
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Female
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Humans
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Infusions, Intravenous
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Magnetic Resonance Imaging
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Middle Aged
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Neoplasms / drug therapy*
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Paclitaxel / administration & dosage
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Paclitaxel / adverse effects
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Paclitaxel / analogs & derivatives*
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Spinal Cord / pathology
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Spinal Cord Diseases / chemically induced*
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Spinal Cord Diseases / diagnosis
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Taxoids*
Substances
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Antineoplastic Agents, Phytogenic
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Taxoids
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Docetaxel
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Paclitaxel