Unique cytomegalovirus intracytoplasmic inclusions in ectocervical cells on a cervical/endocervical smear

Diagn Cytopathol. 1998 Feb;18(2):110-2. doi: 10.1002/(sici)1097-0339(199802)18:2<110::aid-dc5>3.0.co;2-j.

Abstract

This case demonstrates unique cytomegalovirus (CMV)-associated intracytoplasmic inclusions in the intermediate squamous cells of a cervical/endocervical smear. These concentric, rod-shaped, perinuclear inclusions were stained for CMV by immunohistochemistry. Cytomegalovirus endocervicitis was also documented on a concurrent cervical biopsy. The finding of these characteristic inclusions on a routine endocervical/cervical smear may provide morphologic evidence for CMV infection in the absence of an adequate endocervical component.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cytomegalovirus / isolation & purification*
  • Cytomegalovirus Infections / metabolism
  • Cytomegalovirus Infections / pathology
  • Cytomegalovirus Infections / virology*
  • Cytoplasm / metabolism
  • Cytoplasm / pathology
  • Cytoplasm / virology
  • Epithelial Cells / metabolism
  • Epithelial Cells / pathology
  • Epithelial Cells / virology*
  • Female
  • Humans
  • Immunohistochemistry
  • Inclusion Bodies, Viral / metabolism
  • Inclusion Bodies, Viral / pathology*
  • Uterine Cervicitis / metabolism
  • Uterine Cervicitis / pathology
  • Uterine Cervicitis / virology*
  • Vaginal Smears
  • Viral Proteins / metabolism

Substances

  • Viral Proteins