Abstract
Two female infants with eyelid hemangiomas developed prickly, rock-hard, subcutaneous crystals following intralesional corticosteroid injections. In each case, the crystals were isocentered on the injection locus and partly eroded the skin, causing local discomfort and inflammation. This complication occurred after two treatment sessions and presented 8 to 9 months after the second injection. An MRI scan showed subcutaneous calcification in the location of the injected orbital hemangioma in one patient. Histopathologic examination confirmed calcification in areas of degenerate hemangioma. There was no recurrence of either hemangioma or calcium deposition following surgical excision. Localized dystrophic calcification may be a late complication of intralesional corticosteroid therapy of periocular hemangiomas.
MeSH terms
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Anti-Inflammatory Agents / administration & dosage
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Anti-Inflammatory Agents / adverse effects*
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Betamethasone / administration & dosage
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Betamethasone / adverse effects
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Betamethasone / analogs & derivatives*
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Calcinosis / chemically induced*
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Calcinosis / pathology
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Calcinosis / surgery
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Eyelid Diseases / chemically induced*
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Eyelid Diseases / pathology
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Eyelid Diseases / surgery
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Eyelid Neoplasms / drug therapy*
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Eyelid Neoplasms / pathology
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Female
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Glucocorticoids / administration & dosage
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Glucocorticoids / adverse effects*
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Hemangioma / drug therapy*
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Hemangioma / pathology
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Humans
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Infant
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Injections, Intralesional
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Triamcinolone Acetonide / administration & dosage
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Triamcinolone Acetonide / adverse effects*
Substances
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Anti-Inflammatory Agents
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Glucocorticoids
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betamethasone sodium phosphate
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Betamethasone
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Triamcinolone Acetonide