Transitional cell carcinoma of the vagina with pagetoid spread pattern

Hum Pathol. 1998 Mar;29(3):299-301. doi: 10.1016/s0046-8177(98)90051-x.

Abstract

A distinctive variant of a papillary noninvasive transitional cell carcinoma (TCC) of the vagina removed from a postmenopausal woman is described. The neoplasm was evaluated by immunohistochemistry. The designation of this neoplasm as a TCC is supported by its morphological features and its coexpression for cytokeratin (CK) 7 and CK 20. Its main feature is pagetoid infiltration into adjacent vaginal epithelium. This is the second reported case involving a transitional cell metaplasia (TCM) of the vagina, a possible precursor lesion of the TCC.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Carcinoma, Transitional Cell / metabolism
  • Carcinoma, Transitional Cell / pathology*
  • Carcinoma, Transitional Cell / surgery
  • Female
  • Humans
  • Immunohistochemistry
  • Keratins / metabolism
  • Metaplasia
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Neoplasms, Second Primary / metabolism
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Postmenopause
  • Urinary Bladder Neoplasms / pathology
  • Urinary Bladder Neoplasms / surgery
  • Vagina / pathology*
  • Vaginal Neoplasms / metabolism
  • Vaginal Neoplasms / pathology*
  • Vaginal Neoplasms / surgery

Substances

  • Keratins