A novel photoaffinity probe for the LTD4 receptor

Bioorg Med Chem. 1998 Jan;6(1):63-72. doi: 10.1016/s0968-0896(97)10011-6.

Abstract

A novel photoaffinity probe for the leukotriene D4 receptor (LTD4) is described. L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair), was found to selectively label a 43-kDa protein in guinea-pig lung membrane previously identified as the LTD4 receptor.

MeSH terms

  • Acetates / chemistry
  • Acetates / metabolism
  • Animals
  • Autoradiography
  • Azirines*
  • Cyclopropanes
  • Guinea Pigs
  • Iodine Radioisotopes
  • Isotope Labeling
  • Leukotriene Antagonists*
  • Lung / metabolism*
  • Membrane Proteins*
  • Molecular Weight
  • Photoaffinity Labels*
  • Quinolines* / chemistry
  • Quinolines* / metabolism
  • Receptors, Leukotriene / metabolism
  • Sulfides

Substances

  • Acetates
  • Azirines
  • Cyclopropanes
  • Iodine Radioisotopes
  • L 745310
  • Leukotriene Antagonists
  • Membrane Proteins
  • Photoaffinity Labels
  • Quinolines
  • Receptors, Leukotriene
  • Sulfides
  • cysteinyl leukotriene receptor 2
  • leukotriene D4 receptor
  • montelukast