Abstract
Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10(-5) and 10(-4) molar concentrations. Interesting selectivities were also recorded between 10(-8) and 10(-6) M for a few compounds. One single compound exhibited good activity against Candida albicans.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology
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Antifungal Agents / chemical synthesis
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Candida albicans
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Drug Screening Assays, Antitumor
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Folic Acid Antagonists / chemical synthesis*
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Folic Acid Antagonists / pharmacology
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Humans
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Microbial Sensitivity Tests
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Quinoxalines / chemical synthesis*
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Quinoxalines / pharmacology
Substances
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Anti-HIV Agents
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Antifungal Agents
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Antineoplastic Agents
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Folic Acid Antagonists
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Quinoxalines