Modulation of morphine-6-glucuronide penetration into the brain by P-glycoprotein

Int J Clin Pharmacol Ther. 1998 Feb;36(2):69-70.
No abstract available

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Animals
  • Blood-Brain Barrier / drug effects
  • Brain / blood supply
  • Brain / metabolism*
  • Cells, Cultured
  • Diffusion
  • Drug Resistance, Multiple*
  • Endothelium, Vascular / metabolism*
  • Immunohistochemistry
  • Membrane Proteins / analysis
  • Morphine / pharmacokinetics
  • Morphine Derivatives / pharmacokinetics*
  • Phosphoproteins / analysis
  • Propranolol / pharmacokinetics
  • Sucrose / pharmacokinetics
  • Swine
  • Vimentin / analysis
  • Zonula Occludens-1 Protein
  • von Willebrand Factor / analysis

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Membrane Proteins
  • Morphine Derivatives
  • Phosphoproteins
  • Vimentin
  • Zonula Occludens-1 Protein
  • von Willebrand Factor
  • Sucrose
  • morphine-6-glucuronide
  • Morphine
  • Propranolol