Brain concentrations of asimadoline in mice: the influence of coadministration of various P-glycoprotein substrates

Int J Clin Pharmacol Ther. 1998 Feb;36(2):76-9.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Acetamides / analysis
  • Acetamides / blood
  • Acetamides / pharmacokinetics*
  • Analgesics, Opioid / pharmacokinetics*
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Brain / metabolism*
  • Carbon Radioisotopes
  • Cyclosporine / pharmacology
  • Dexamethasone / pharmacology
  • Digoxin / pharmacology
  • Drug Interactions
  • Enzyme Inhibitors / pharmacology
  • Glucocorticoids / pharmacology
  • Immunosuppressive Agents / pharmacology
  • Male
  • Mice
  • Ondansetron / pharmacology
  • Pilot Projects
  • Pyrrolidines / analysis
  • Pyrrolidines / blood
  • Pyrrolidines / pharmacokinetics*
  • Serotonin Antagonists / pharmacology
  • Vinblastine / pharmacology

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Acetamides
  • Analgesics, Opioid
  • Antineoplastic Agents, Phytogenic
  • Carbon Radioisotopes
  • Enzyme Inhibitors
  • Glucocorticoids
  • Immunosuppressive Agents
  • Pyrrolidines
  • Serotonin Antagonists
  • Ondansetron
  • Vinblastine
  • Digoxin
  • Dexamethasone
  • Cyclosporine
  • asimadoline