Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism

A G Herzog; P Klein; A R Jacobs

doi:10.1212/wnl.50.3.782

Testosterone versus testosterone and testolactone in treating reproductive and sexual dysfunction in men with epilepsy and hypogonadism

Neurology. 1998 Mar;50(3):782-4. doi: 10.1212/wnl.50.3.782.

Authors

A G Herzog¹, P Klein, A R Jacobs

Affiliation

¹ Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

PMID: 9521275
DOI: 10.1212/wnl.50.3.782

Abstract

Antiepileptic drug-induced reductions in serum levels of biologically active testosterone and elevations in serum estradiol (E2) may contribute to sexual dysfunction among men with epilepsy. Treatment using a combination of testosterone and the aromatase inhibitor testolactone may have significantly better effects on sexual function and also seizure frequency than testosterone alone.

Publication types

Clinical Trial

MeSH terms

Adult
Aromatase Inhibitors
Drug Therapy, Combination
Enzyme Inhibitors / therapeutic use*
Epilepsy / blood
Epilepsy / complications*
Epilepsy / physiopathology
Estradiol / blood
Humans
Hypogonadism / blood
Hypogonadism / complications*
Hypogonadism / physiopathology
Male
Middle Aged
Reproduction / drug effects*
Sexual Dysfunctions, Psychological / drug therapy*
Sexual Dysfunctions, Psychological / etiology
Testolactone / therapeutic use*
Testosterone / blood
Testosterone / therapeutic use*
Treatment Outcome

Substances

Aromatase Inhibitors
Enzyme Inhibitors
Testosterone
Estradiol
Testolactone