Abstract
In a study of 48 patients with coronary artery disease and evidence of ischemia during exercise and daily life, metoprolol reduced the threshold of myocardial ischemia in a dose-dependent manner. This effect of beta blockers is probably due to increased coronary tone.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Activities of Daily Living*
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Adrenergic beta-Antagonists / pharmacology*
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Blood Pressure
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Dose-Response Relationship, Drug
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Electrocardiography, Ambulatory
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Exercise*
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Heart Rate
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Humans
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Metoprolol / pharmacology*
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Myocardial Ischemia / physiopathology
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Myocardial Ischemia / prevention & control*
Substances
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Adrenergic beta-Antagonists
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Metoprolol