Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules

J Immunol. 1998 Apr 1;160(7):3096-100.

Abstract

Leukocyte activation can be negatively regulated by inhibitory receptors specific for MHC class I molecules. While one inhibitory receptor, Ig-like transcript 2 (ILT2), is expressed by all lymphoid and myelomonocytic cell types, other receptors display a more selective tissue distribution. Here we characterize an inhibitory receptor, termed ILT4, which is selectively expressed in monocytes, macrophages, and dendritic cells (DCs), binds classical class I molecules and the nonclassical class I molecules HLA-G, and transduces negative signals that can inhibit early signaling events triggered by stimulatory receptors. ILT4 may control inflammatory responses and cytotoxicity mediated by myelomonocytic cells and may modulate their Ag-presenting functions, focusing immune responses to microbial challenges and avoiding autoreactivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes
  • Cell Line
  • Cells, Cultured
  • Dendritic Cells
  • HLA Antigens / metabolism
  • Histocompatibility Antigens Class I / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Killer Cells, Natural
  • Lymphocyte Activation / immunology
  • Macrophage Activation / immunology
  • Macrophages
  • Mast Cells / enzymology
  • Mast Cells / metabolism
  • Membrane Glycoproteins
  • Mice
  • Molecular Weight
  • Monocytes
  • Protein Binding
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases / metabolism
  • Rats
  • Rats, Wistar
  • Receptors, Immunologic / biosynthesis*
  • Receptors, Immunologic / physiology
  • Serotonin / metabolism
  • Serotonin Antagonists / immunology
  • Signal Transduction / immunology

Substances

  • HLA Antigens
  • Histocompatibility Antigens Class I
  • Intracellular Signaling Peptides and Proteins
  • LILRB2 protein, human
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • Serotonin Antagonists
  • Serotonin
  • PTPN11 protein, human
  • PTPN6 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 11
  • Protein Tyrosine Phosphatase, Non-Receptor Type 6
  • Protein Tyrosine Phosphatases
  • Ptpn11 protein, mouse
  • Ptpn11 protein, rat
  • Ptpn6 protein, mouse
  • Ptpn6 protein, rat