The main tasks of MRI diagnosis of the brain for unspecific neurological symptoms such as, for example, headache, psychiatric diseases, subjective cognitive deficits, and retarded development in children generally involve the reliable exclusion of morphologically detectable lesions. Since there can be no universally accepted protocol for all possible situations, a basis protocol is given under consideration of modern fast spin echo, turbo FLAIR, and T2*-weighted gradient echo sequences to obtain important information in a short time. In addition, useful supplements are suggested that can proved further relevant data in dependence on the respective condition.