Late components of the event-related potentials and their topography in Parkinson's disease

Mov Disord. 1998 Mar;13(2):262-7. doi: 10.1002/mds.870130211.

Abstract

Late components of the event-related potential (ERP; N100, P200, N200, and P300) were elicited using an auditory oddball paradigm (with a button-press response to target stimuli) in 15 Parkinson's disease (PD) patients and 50 normal control subjects. Compared with control subjects, PD subjects showed a significant decrease in N200 amplitude. Between-group topographical differences in N200 amplitude were evident at central (C3, Cz, C4) and temporal (T5, T3, T4, T6) regions. The results may reflect a deficit in response selection in PD possibly resulting from a dysfunction associated with the abnormalities in the central and temporal regions found to have a decreased N200 amplitude compared with normal control subjects in this study.

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Aged
  • Brain Mapping
  • Cerebral Cortex / physiopathology*
  • Electroencephalography*
  • Event-Related Potentials, P300 / physiology
  • Evoked Potentials / physiology*
  • Evoked Potentials, Auditory / physiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / physiopathology*
  • Reaction Time / physiology
  • Reference Values
  • Signal Processing, Computer-Assisted