Abstract
The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.
MeSH terms
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Amides / chemistry*
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Animals
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Guinea Pigs
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Histamine / pharmacology
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Histamine H1 Antagonists / chemical synthesis
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Histamine H1 Antagonists / chemistry
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Histamine H1 Antagonists / pharmacology*
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Ileum / drug effects
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Ileum / physiology
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In Vitro Techniques
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Muscle Contraction / drug effects
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Structure-Activity Relationship
Substances
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Amides
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Histamine H1 Antagonists
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Histamine