Clinicopathological features of chronic inflammatory demyelinating polyradiculoneuropathy in childhood

J Neurol Sci. 1998 Jan 21;154(1):66-71. doi: 10.1016/s0022-510x(97)00216-5.

Abstract

The clinical, electrophysiological, and pathological findings, and the therapeutic characteristics in ten children with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), whose onset age was less than 16 years, were evaluated. The clinical progression pattern of the initial phase divided the patients into two groups. One group (six patients) showed a subacute progression for up to 2 months after onset and a subsided progression over 3 months. Three patients in this group had a preceding febrile episode. The other group (four patients) showed a chronic insidious progression for more than 3 months. The former group of patients revealed a favourable response to corticosteroid therapy as compared with the latter group. However, other clinical and laboratory features at the peak impairment were not distinguishable between these two groups. Motor dominant neuropathy was common to all patients, and only three cases showed sensory disturbance on the distal limbs. No cases revealed cranial nerve involvement. Motor and sensory nerve conduction and sural nerve biopsy studies revealed the demyelinating nature of the neuropathy. These clinicopathological features suggest that the subacute progression form frequently associated with prodromal episode and rather favourable corticosteroid response is characteristic in childhood CIDP, while the chronic insidious progression form is indistinguishable from the common adult CIDP.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Child
  • Child, Preschool
  • Chronic Disease
  • Demyelinating Diseases* / complications
  • Demyelinating Diseases* / pathology
  • Demyelinating Diseases* / physiopathology
  • Demyelinating Diseases* / therapy
  • Electrophysiology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Myelin Sheath / pathology
  • Neural Conduction
  • Neurologic Examination
  • Polyradiculoneuropathy* / complications
  • Polyradiculoneuropathy* / pathology
  • Polyradiculoneuropathy* / physiopathology
  • Polyradiculoneuropathy* / therapy
  • Sural Nerve / pathology
  • Sural Nerve / physiopathology
  • Treatment Outcome

Substances

  • Adrenal Cortex Hormones