PACAP as low as 10(-13) M raises cytosolic Ca2+ activity in pancreatic B-cells by augmenting Ca2+ influx through L-type Ca2+ channels to trigger insulin release

Adv Exp Med Biol. 1997:426:165-71. doi: 10.1007/978-1-4899-1819-2_22.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / drug effects
  • Calcium Channels / physiology*
  • Calcium Channels, L-Type
  • Cells, Cultured
  • Cytosol / drug effects
  • Cytosol / metabolism
  • Dose-Response Relationship, Drug
  • Glucose / pharmacology
  • Insulin / metabolism*
  • Insulin Secretion
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / physiology*
  • Kinetics
  • Neuropeptides / pharmacology*
  • Neurotransmitter Agents / pharmacology
  • Nitrendipine / pharmacology
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Rats
  • Rats, Wistar
  • Tolbutamide / pharmacology

Substances

  • Adcyap1 protein, rat
  • Calcium Channels
  • Calcium Channels, L-Type
  • Insulin
  • Neuropeptides
  • Neurotransmitter Agents
  • Pituitary Adenylate Cyclase-Activating Polypeptide
  • Tolbutamide
  • Nitrendipine
  • Glucose
  • Calcium