New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

K A Dekker; T Inagaki; T D Gootz; L H Huang; Y Kojima; W E Kohlbrenner; Y Matsunaga; P R McGuirk; E Nomura; T Sakakibara; S Sakemi; Y Suzuki; Y Yamauchi; N Kojima

doi:10.7164/antibiotics.51.145

New quinolone compounds from Pseudonocardia sp. with selective and potent anti-Helicobacter pylori activity: taxonomy of producing strain, fermentation, isolation, structural elucidation and biological activities

J Antibiot (Tokyo). 1998 Feb;51(2):145-52. doi: 10.7164/antibiotics.51.145.

Authors

K A Dekker¹, T Inagaki, T D Gootz, L H Huang, Y Kojima, W E Kohlbrenner, Y Matsunaga, P R McGuirk, E Nomura, T Sakakibara, S Sakemi, Y Suzuki, Y Yamauchi, N Kojima

Affiliation

¹ Central Research Division, Pfizer Pharmaceuticals Inc., Aichi, Japan.

PMID: 9544935
DOI: 10.7164/antibiotics.51.145

Abstract

Eight novel quinolones with anti-Helicobacter pylori activity were isolated from the actinomycete Pseudonocardia sp. CL38489. The quinolones were very potent against H. pylori with MICs up to 0.1 ng/ml. The quinolones appear to be specific for H. pylori, since they did not show antimicrobial activity when tested against a panel of other microorganisms.

Publication types

Comparative Study

MeSH terms

4-Quinolones
Actinomycetaceae
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology*
Fermentation
Helicobacter pylori / drug effects*
Microbial Sensitivity Tests
Structure-Activity Relationship

Substances

4-Quinolones
Anti-Infective Agents