Primary Sjögren's syndrome complicated by sarcoidosis

Intern Med. 1998 Feb;37(2):174-8. doi: 10.2169/internalmedicine.37.174.

Abstract

Sjögren's syndrome and sarcoidosis share several common features, such as keratoconjunctivitis sicca, swelling of parotid glands, lung involvement, cutaneous anergy, T cell-mediated immunodeficiency, an increased CD4+/CD8+ lymphocyte ratio, and association with the human leucocyte antigen (HLA)-B 8 and DR 3 haplotypes. However, only five patients with primary Sjögren's syndrome and sarcoidosis have been previously reported in the English language literature. The rare case of a 49-year-old Japanese woman with primary Sjögren's syndrome complicated by sarcoidosis is described. The serum angiotensin-converting enzyme level was increased, and histological examination of lung and skin biopsies revealed noncaseating granulomas, indicating that her primary Sjögren's syndrome was complicated by sarcoidosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Female
  • Granuloma / pathology
  • Humans
  • Lung Diseases / pathology
  • Middle Aged
  • Peptidyl-Dipeptidase A / blood
  • Sarcoidosis / complications*
  • Sarcoidosis / diagnosis
  • Sarcoidosis / enzymology
  • Sjogren's Syndrome / complications*
  • Sjogren's Syndrome / diagnosis
  • Sjogren's Syndrome / enzymology
  • Skin Diseases / pathology

Substances

  • Peptidyl-Dipeptidase A