Localization of the mRNAs for two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain

H Sakagami; S Saito; T Kitani; S Okuno; H Fujisawa; H Kondo

doi:10.1016/s0169-328x(97)00362-8

Localization of the mRNAs for two isoforms of Ca2+/calmodulin-dependent protein kinase kinases in the adult rat brain

Brain Res Mol Brain Res. 1998 Mar 1;54(2):311-5. doi: 10.1016/s0169-328x(97)00362-8.

Authors

H Sakagami¹, S Saito, T Kitani, S Okuno, H Fujisawa, H Kondo

Affiliation

¹ Department of Histology, Tohoku University, School of Medicine, Sendai 980, Japan. [email protected]

PMID: 9555071
DOI: 10.1016/s0169-328x(97)00362-8

Abstract

Ca2+/calmodulin-dependent protein kinase (CaM kinase) I and IV are thought to be activated by CaM kinase kinases (CaMKK). We examined the distribution of mRNAs for two isoforms (alpha and beta) of CaMKKs in the brain by in situ hybridization histochemistry. In the adult rat brain, CaMKK alpha mRNAs are widely distributed throughout the brain, whereas CaMKK beta mRNAs are restricted to some neuronal populations, particularly the cerebellar granule cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / enzymology*
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Calcium-Calmodulin-Dependent Protein Kinases / genetics*
In Situ Hybridization
Isoenzymes / genetics*
Protein Serine-Threonine Kinases / genetics*
Protein Serine-Threonine Kinases / isolation & purification
RNA, Messenger / analysis*
Rats
Rats, Wistar

Substances

Isoenzymes
RNA, Messenger
Protein Serine-Threonine Kinases
Calcium-Calmodulin-Dependent Protein Kinase Kinase
Calcium-Calmodulin-Dependent Protein Kinases