Effect of the administration of fish oil by gavage on activities of antioxidant enzymes of rat lymphoid organs

Gen Pharmacol. 1998 May;30(5):759-62. doi: 10.1016/s0306-3623(97)00334-0.

Abstract

1. The effect of administration of fish oil by gavage on catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities of the lymphoid organs and liver was compared with those of soybean oil and cocoa butter. 2. Fish oil did not affect the activities of SOD and CAT but reduced that of GSH-Px in the spleen. In contrast, cocoa butter reduced the CAT activity in the thymus and liver, and soybean oil decreased CAT activity in the thymus. 3. The content of thiobarbituric acid reactive substances of the lymphoid organs was not modified but was increased in plasma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / drug effects*
  • Catalase / metabolism
  • Dietary Fats / pharmacology
  • Fish Oils / pharmacology*
  • Glutathione Peroxidase / drug effects*
  • Glutathione Peroxidase / metabolism
  • Lymphoid Tissue / drug effects*
  • Lymphoid Tissue / enzymology
  • Male
  • Rats
  • Soybean Oil / pharmacology
  • Spleen / drug effects
  • Spleen / enzymology
  • Superoxide Dismutase / drug effects*
  • Superoxide Dismutase / metabolism
  • Thymus Gland / drug effects
  • Thymus Gland / enzymology

Substances

  • Dietary Fats
  • Fish Oils
  • cocoa butter
  • Soybean Oil
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase