Diagnosis of dengue by using reverse transcriptase-polymerase chain reaction

Mem Inst Oswaldo Cruz. 1997 Sep-Oct;92(5):595-9. doi: 10.1590/s0074-02761997000500006.

Abstract

A rapid identification of dengue viruses from clinical samples by using a nested reverse transcriptase-polymerase chain reaction (RT-PCR) procedure was carried out for diagnostic and epidemiological purposes. RT-PCR identified DEN-1 and DEN-2 viruses in 41% (41/100) of previously confirmed cases and provided an accurate confirmation of DHF in four fatal cases. RT-PCR was also useful for detecting and typing dengue viruses in suspected cases, allowing a rapid identification of new serotypes in endemic areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil / epidemiology
  • Dengue / diagnosis*
  • Dengue / epidemiology
  • Dengue Virus / isolation & purification*
  • Humans
  • Polymerase Chain Reaction / methods*