Mitochondrial abnormalities in selenium-deficient myopathy

Muscle Nerve. 1998 May;21(5):637-9. doi: 10.1002/(sici)1097-4598(199805)21:5<637::aid-mus10>3.0.co;2-s.

Abstract

We report a man who developed selenium-deficient myopathy during long-term parenteral nutrition. Muscle biopsy showed marked mitochondrial depletion in the deep sarcoplasm and enlarged mitochondria at the periphery mainly in type 2 fibers. Muscle weakness improved gradually after the second course of selenium supplementation. The peculiar mitochondrial abnormalities in muscle fibers appear to play a key role in the pathogenesis of selenium-deficient myopathy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Humans
  • Male
  • Microscopy, Electron
  • Mitochondria / pathology*
  • Mitochondrial Myopathies / drug therapy
  • Mitochondrial Myopathies / etiology*
  • Mitochondrial Myopathies / pathology*
  • Muscle Weakness / drug therapy
  • Muscle Weakness / physiopathology
  • Muscles / pathology
  • Muscular Diseases / drug therapy
  • Muscular Diseases / etiology*
  • Muscular Diseases / pathology*
  • Parenteral Nutrition / adverse effects
  • Selenium / deficiency*
  • Selenium / therapeutic use
  • Time Factors

Substances

  • Selenium