Alternating radiotherapy and chemotherapy in limited disease small cell lung cancer

C Le Péchoux; R Arriagada; T Le Chevalier; M Tarayre; P Ruffié; P Baldeyrou; J J Bretel; B Pellae-Cosset; C Hanzen; M Martin; P Duroux

doi:10.1016/s0167-8140(97)00189-8

Alternating radiotherapy and chemotherapy in limited disease small cell lung cancer

Radiother Oncol. 1998 Mar;46(3):257-61. doi: 10.1016/s0167-8140(97)00189-8.

Authors

C Le Péchoux¹, R Arriagada, T Le Chevalier, M Tarayre, P Ruffié, P Baldeyrou, J J Bretel, B Pellae-Cosset, C Hanzen, M Martin, P Duroux

Affiliation

¹ Lung Disease Unit, Institut Gustave-Roussy, Villejuif, France.

PMID: 9572618
DOI: 10.1016/s0167-8140(97)00189-8

Abstract

In a pilot study of 29 patients treated for localized small cell lung cancer, three new approaches were introduced, i.e. an increased initial drug dose, an early alternation of chemotherapy and thoracic radiotherapy and initial accelerated and hyperfractionated irradiation. The results were interesting. However, a high rate of fatal toxicity (21%) was observed.

Publication types

Clinical Trial
Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Antineoplastic Combined Chemotherapy Protocols / adverse effects
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Carcinoma, Small Cell / drug therapy*
Carcinoma, Small Cell / mortality
Carcinoma, Small Cell / radiotherapy*
Combined Modality Therapy
Disease-Free Survival
Dose-Response Relationship, Radiation
Female
Follow-Up Studies
Humans
Lung Neoplasms / drug therapy*
Lung Neoplasms / mortality
Lung Neoplasms / radiotherapy*
Male
Middle Aged
Pilot Projects
Radiation Dosage
Radiation Injuries / diagnosis
Radiation Injuries / etiology
Radiotherapy, Adjuvant
Radiotherapy, High-Energy* / adverse effects
Survival Rate