Abstract
Clinafloxacin, levofloxacin, sparfloxacin and trovafloxacin were tested by Etest against 188 Streptococcus pneumoniae isolates. Clinafloxacin and trovafloxacin were 2-4-fold more potent than sparfloxacin and 8-fold more than levofloxacin. Two isolates, both serotype 6, with high-level quinolone resistance (> or = 8 micrograms/ml) were detected. The Etest is a practical means for determining S. pneumoniae susceptibilities to new fluoroquinolones.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Fluoroquinolones*
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Levofloxacin
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Microbial Sensitivity Tests / methods
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Naphthyridines / pharmacology
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Ofloxacin / pharmacology
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Quinolones / pharmacology
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Streptococcus pneumoniae / drug effects*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Naphthyridines
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Quinolones
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Levofloxacin
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clinafloxacin
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trovafloxacin
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Ofloxacin
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sparfloxacin