Abstract
A mitochondrial mutation at nucleotide 1555 has been reported to be susceptible to aminoglycoside antibiotics as well as one of the causes of nonsyndromic sensorineural hearing loss. We herewith report 2 cases bearing the 1555 A-->G mitochondrial mutation who had hearing loss after short-term exposure to the new aminoglycoside antibiotic, isepamicin sulfate. Even when using aminoglycoside antibiotics with milder side effects, careful attention should be paid in applying them to patients with particular genetic backgrounds.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Anti-Bacterial Agents / adverse effects*
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Audiometry
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DNA, Mitochondrial / genetics
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Female
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Genetic Predisposition to Disease
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Gentamicins / adverse effects
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Hearing Loss, Sensorineural / chemically induced*
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Hearing Loss, Sensorineural / genetics*
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Humans
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Pedigree
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Point Mutation / drug effects
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Polymerase Chain Reaction
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Vestibular Function Tests
Substances
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Anti-Bacterial Agents
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DNA, Mitochondrial
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Gentamicins
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isepamicin