Abstract
Detection of human immunodeficiency virus-type 1 (HIV-1) on only one or a few occasions in infants born to infected mothers has been interpreted to indicate that infection may be transient rather than persistent. Forty-two cases of suspected transient HIV-1 viremia among 1562 perinatally exposed seroreverting infants and one mother were reanalyzed. HIV-1 env sequences were not found in specimens from 20; in specimens from 6, somatic genetic analysis revealed that specimens were mistakenly attributed to an infant; and in specimens from 17, phylogenetic analysis failed to demonstrate the expected linkage between the infant's and the mother's virus. These findings argue that transient HIV-1 infection, if it exists, will only rarely be satisfactorily documented.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA, Viral / analysis
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DNA, Viral / genetics
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Diagnostic Errors
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Equipment Contamination
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Female
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Genes, env
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HIV Infections / immunology
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HIV Infections / transmission
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HIV Infections / virology*
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HIV-1 / genetics*
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HIV-1 / isolation & purification*
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Humans
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Infant
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Infant, Newborn
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Infectious Disease Transmission, Vertical
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Molecular Sequence Data
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Phylogeny
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Polymerase Chain Reaction
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RNA, Viral / analysis
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Specimen Handling*
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T-Lymphocytes, Cytotoxic / immunology
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Viremia / virology
Associated data
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GENBANK/AF065488
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GENBANK/AF065489
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GENBANK/AF065490
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GENBANK/AF065491
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GENBANK/AF065492
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GENBANK/AF065493
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GENBANK/AF065494
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GENBANK/AF065495
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GENBANK/AF065496
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GENBANK/AF065497
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GENBANK/AF065498
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GENBANK/AF065499
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GENBANK/AF065500
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GENBANK/AF065501
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GENBANK/AF065502
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GENBANK/AF065503
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GENBANK/AF065504
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GENBANK/AF065505
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GENBANK/AF065506
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GENBANK/AF065507
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GENBANK/AF065508
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GENBANK/AF065509
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GENBANK/AF065510
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GENBANK/AF065511
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GENBANK/AF065512
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GENBANK/AF065513
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GENBANK/AF065514
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GENBANK/AF065515
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GENBANK/AF065516
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GENBANK/AF065517