Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique

S Kohgo; A Umeda; H Ozaki; K Shinozuka; H Sawai

Synthesis of oligodeoxyribonucleotide containing novel C-5 reactive 2'-deoxyuridine derivative and its functional modification via post-synthetic technique

Nucleic Acids Symp Ser. 1997:(37):29-30.

Authors

S Kohgo¹, A Umeda, H Ozaki, K Shinozuka, H Sawai

Affiliation

¹ Department of Chemistry, Faculty of Engineering, Gunma University, Japan.

PMID: 9585983

Abstract

2'-Deoxyuridine derivatives bearing an activated ester at C-5 position were synthesized and was examined their use for the preparation of modified oligodeoxyribonucleotides (ODNs) by a post-modification method. The ODNs containing cyanomethyl ester at C-5 position of the deoxyuridine residue reacted easily with a primary amine of several functional molecules under the mild condition to give the corresponding modified ODNs.

MeSH terms

Base Sequence
Deoxyuridine / analogs & derivatives*
Deoxyuridine / chemistry
Indicators and Reagents
Molecular Structure
Oligodeoxyribonucleotides / chemical synthesis*
Oligodeoxyribonucleotides / chemistry

Substances

Indicators and Reagents
Oligodeoxyribonucleotides
Deoxyuridine