Clinical predictors of nephritis in systemic lupus erythematosus

Ann Acad Med Singap. 1998 Jan;27(1):16-20.

Abstract

We identified clinical predictors of lupus nephritis presenting more than 6 months after the diagnosis of lupus in a cohort of 335 lupus patients. Almost 24% (80/335) of patients developed nephritis more than 6 months after the diagnosis of lupus. Using a Cox proportional hazards model, we found hypertension, thrombocytopaenia and leukopaenia to be associated with lupus nephritis presenting more than 6 months after diagnosis, with adjusted relative risks of 2.5 (95% CI 1.3 to 4.7), 4.3 (95% CI 1.7 to 10.8) and 3.2 (95% CI 1.7 to 6.2) respectively. In this cohort, hypertension, thrombocytopaenia and leukopaenia were associated with lupus nephritis presenting more than 6 months after the diagnosis of lupus.

MeSH terms

  • Adult
  • Age Distribution
  • Cohort Studies
  • Confidence Intervals
  • Female
  • Humans
  • Hypertension / complications
  • Hypertension / epidemiology*
  • Incidence
  • Leukopenia / complications
  • Leukopenia / epidemiology*
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / diagnosis
  • Lupus Nephritis / diagnosis
  • Lupus Nephritis / epidemiology
  • Lupus Nephritis / etiology*
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Proteinuria / complications
  • Proteinuria / epidemiology*
  • Registries
  • Retrospective Studies
  • Risk Factors
  • Sex Distribution
  • Singapore / epidemiology
  • Thrombocytopenia / complications
  • Thrombocytopenia / epidemiology*