Abstract
Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G-CSF did not influence the proliferative activity of MmB16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB16.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Cell Division / drug effects
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Disease Models, Animal
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Drug Screening Assays, Antitumor
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Female
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Granulocyte Colony-Stimulating Factor / therapeutic use*
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Macrophages / drug effects
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Macrophages / metabolism
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Melanoma, Experimental / drug therapy*
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Mice
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Mice, Inbred C57BL
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Mice, Inbred DBA
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Nitric Oxide / biosynthesis
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Recombinant Proteins
Substances
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Antineoplastic Agents
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Recombinant Proteins
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Granulocyte Colony-Stimulating Factor
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Nitric Oxide