Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration

H L Kaufman; M Roden; D Nathanson; T M Basso; D J Schwartzentruber; S M Holland

doi:10.1016/s0022-3468(98)90212-3

Splenectomy in a child with chronic Mycobacterium avium complex infection and splenic sequestration

J Pediatr Surg. 1998 May;33(5):761-3. doi: 10.1016/s0022-3468(98)90212-3.

Authors

H L Kaufman¹, M Roden, D Nathanson, T M Basso, D J Schwartzentruber, S M Holland

Affiliation

¹ Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

PMID: 9607493
DOI: 10.1016/s0022-3468(98)90212-3

Abstract

Mycobacterium avium complex infections (MAC) are being reported with increasing frequency in immunocompromised patients. When these infections become resistant to standard antibiotic therapy, treatment with interferon-gamma (IFN-gamma) can be helpful. Pain, fever, splenic enlargement, and cytopenias caused by splenic sequestration developed during IFN-gamma treatment in a 9-year-old boy and were successfully treated by splenectomy. The development of IFN-gamma-induced splenic sequestration and cytopenias in MAC-infected patients represents a new indication for splenectomy.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use
Child
Chronic Disease
Follow-Up Studies
Humans
Interferon-gamma / adverse effects*
Interferon-gamma / therapeutic use
Male
Mycobacterium avium Complex / isolation & purification*
Mycobacterium avium-intracellulare Infection / complications
Mycobacterium avium-intracellulare Infection / diagnosis
Mycobacterium avium-intracellulare Infection / drug therapy*
Splenectomy*
Splenomegaly / chemically induced*
Splenomegaly / diagnostic imaging
Splenomegaly / surgery*
Tomography, X-Ray Computed

Substances

Anti-Bacterial Agents
Interferon-gamma