Abstract
Using a pharmacological probe, procaine hydrochloride, the authors elicited consistent and selective activation of anterior limbic and paralimbic structures in normal human volunteers as documented by H215O positron emission tomography. This activation was associated with a range of emotional, somatic, and visceral experiences, often similar to those experienced during the aura of temporal lobe epilepsy. Several subjects also experienced panic attacks. This study confirms that selective anterior limbic/paralimbic activity in normal human volunteers evokes many emotional phenomena as well as common "ill-defined" symptoms observed in clinical conditions. The present combination of procaine challenge and neuroimaging provides a noninvasive procedure to probe the contribution of different anterior limbic and paralimbic structures to normal human emotions and to neuropsychiatric disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Anxiety / chemically induced
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Attention / drug effects
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Attention / physiology
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Brain / diagnostic imaging
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Brain / drug effects
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Brain / physiology
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Cerebrovascular Circulation / drug effects*
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Cognition / drug effects
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Cognition / physiology
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Depersonalization / chemically induced
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Emotions / drug effects
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Emotions / physiology*
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Factor Analysis, Statistical
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Female
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Humans
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Limbic System* / diagnostic imaging
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Limbic System* / drug effects
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Limbic System* / physiology
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Male
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Neocortex / drug effects
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Neocortex / physiology
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Neural Pathways / drug effects
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Neural Pathways / physiology
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Oxygen Radioisotopes
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Perceptual Distortion / drug effects
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Perceptual Distortion / physiology
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Procaine / pharmacology*
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Sensation Disorders / chemically induced
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Tomography, Emission-Computed*
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Water
Substances
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Oxygen Radioisotopes
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Water
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Procaine