Abstract
We studied the presence of tax and ltr genes from human T-cell lymphotropic virus type I (HTLV-I) provirus in the peripheral blood mononuclear cells from 15 seronegative patients with tropical spastic paraparesis or HTLV-I-associated myelopathy by PCR. Only a region of the tax gene from 10 patients was amplified. The nucleotide homologies of six Chilean isolates to the ATK-1 clone ranged between 98.7 and 99.4%.
MeSH terms
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Adult
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Aged
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Base Sequence
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Blotting, Western
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Chile
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Defective Viruses / genetics
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Defective Viruses / isolation & purification*
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Female
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Fluorescent Antibody Technique, Indirect
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Genes, pX
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HTLV-I Antibodies / blood
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HTLV-I Infections / immunology
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HTLV-I Infections / virology*
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Human T-lymphotropic virus 1 / genetics
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Human T-lymphotropic virus 1 / isolation & purification*
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Humans
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Male
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Middle Aged
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Molecular Sequence Data
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Paraparesis, Tropical Spastic / immunology
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Paraparesis, Tropical Spastic / virology*
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Polymerase Chain Reaction
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Proviruses / genetics
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Proviruses / isolation & purification*