Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene

S Ishikawa; M Kai; Y Murata; M Tamari; Y Daigo; T Murano; M Ogawa; Y Nakamura

doi:10.1007/s100380050054

Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene

J Hum Genet. 1998;43(2):132-4. doi: 10.1007/s100380050054.

Authors

S Ishikawa¹, M Kai, Y Murata, M Tamari, Y Daigo, T Murano, M Ogawa, Y Nakamura

Affiliation

¹ Laboratory of Molecular Medicine, University of Tokyo, Japan.

PMID: 9621519
DOI: 10.1007/s100380050054

Abstract

Activins, members of a family of proteins that includes transforming growth factor-beta (TGF-beta), are gonadal polypeptide hormones that stimulate secretion of follicle-stimulating hormone (FSH). During large-scale sequencing analysis of a 1.2-Mb fragment of human genomic DNA on 3p22-p21.3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Activin Receptors, Type II
Chromosome Mapping
Chromosome Walking
Chromosomes, Human, Pair 3 / genetics*
DNA, Neoplasm / genetics
Exons / genetics
Genes*
Humans
In Situ Hybridization, Fluorescence
Lung Neoplasms / genetics
Receptors, Growth Factor / genetics*
Sequence Deletion

Substances

DNA, Neoplasm
Receptors, Growth Factor
Activin Receptors, Type II

Associated data

GENBANK/AB008681