Treatment of hemoglobin Bart's hydrops with bone marrow transplantation

K W Chik; M M Shing; C K Li; T F Leung; K S Tsang; H L Yuen; S B Cheng; P M Yuen

doi:10.1016/s0022-3476(98)70406-8

Treatment of hemoglobin Bart's hydrops with bone marrow transplantation

J Pediatr. 1998 Jun;132(6):1039-42. doi: 10.1016/s0022-3476(98)70406-8.

Authors

K W Chik¹, M M Shing, C K Li, T F Leung, K S Tsang, H L Yuen, S B Cheng, P M Yuen

Affiliation

¹ Department of Pediatrics, Prince of Wales Hospital, Chinese University of Hong Kong.

PMID: 9627601
DOI: 10.1016/s0022-3476(98)70406-8

Abstract

A 21-month-old girl with hemoglobin Bart's hydrops received bone marrow transplantation (BMT) from a matched sibling. No major BMT-related complications developed. Hemoglobin levels remained greater than 10 gm/dl for 20 months without blood transfusion support despite the presence of residual host hemopoietic cells from 2 months after BMT. We suggest consideration of this therapeutic option for surviving patients.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Bone Marrow Transplantation*
Female
Globins / genetics
Hemoglobins, Abnormal* / genetics
Humans
Infant
Transplantation Conditioning
alpha-Thalassemia / blood
alpha-Thalassemia / genetics
alpha-Thalassemia / therapy*

Substances

Hemoglobins, Abnormal
Globins
hemoglobin Bart's