Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system

K R Oliver; A Wainwright; R P Heavens; R G Hill; D J Sirinathsinghji

doi:10.1016/s0169-328x(98)00052-7

Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system

Brain Res Mol Brain Res. 1998 Jun 1;57(1):149-54. doi: 10.1016/s0169-328x(98)00052-7.

Authors

K R Oliver¹, A Wainwright, R P Heavens, R G Hill, D J Sirinathsinghji

Affiliation

¹ Merck, Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, Essex CM20 2QR, UK. [email protected]

PMID: 9630585
DOI: 10.1016/s0169-328x(98)00052-7

Abstract

Recent cloning studies have isolated receptors which confer specific responsiveness to calcitonin gene related peptide (CGRP) and the related peptide adrenomedullin. Using in situ hybridisation, we demonstrate the heterogenous distribution of the mRNAs of two proposed CGRP1 receptors (RDC-1 and calcitonin receptor-like receptor, CRLR) in the rat brain. Adrenomedullin receptor mRNA was weakly expressed, principally in the cerebellum. These findings may assist in the determination of the function of these largely uncharacterised receptors.

MeSH terms

Amygdala / chemistry
Animals
Brain Chemistry*
GTP-Binding Proteins / genetics
In Situ Hybridization
Male
Membrane Proteins / genetics*
Neostriatum / chemistry
Oligonucleotide Probes
Pia Mater / chemistry
RNA, Messenger / analysis
Rats
Rats, Sprague-Dawley
Receptors, Adrenomedullin
Receptors, Calcitonin Gene-Related Peptide / genetics*
Receptors, Peptide*

Substances

Membrane Proteins
Oligonucleotide Probes
RNA, Messenger
Receptors, Adrenomedullin
Receptors, Calcitonin Gene-Related Peptide
Receptors, Peptide
GTP-Binding Proteins