Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists

J Med Chem. 1998 Jun 18;41(13):2175-9. doi: 10.1021/jm980194h.
No abstract available

MeSH terms

  • Animals
  • CHO Cells
  • Cell Line
  • Cricetinae
  • Cyclic AMP / agonists
  • Growth Hormone / metabolism
  • Humans
  • In Vitro Techniques
  • Indoles* / chemical synthesis
  • Indoles* / chemistry
  • Indoles* / metabolism
  • Indoles* / pharmacology
  • Ligands
  • Mice
  • Models, Molecular
  • Piperidines* / chemical synthesis
  • Piperidines* / chemistry
  • Piperidines* / metabolism
  • Piperidines* / pharmacology
  • Pituitary Gland / cytology
  • Pituitary Gland / drug effects
  • Pituitary Gland / metabolism
  • Rats
  • Receptors, Somatostatin / agonists*
  • Receptors, Somatostatin / metabolism
  • Structure-Activity Relationship

Substances

  • Indoles
  • L 54264
  • Ligands
  • Piperidines
  • Receptors, Somatostatin
  • Growth Hormone
  • somatostatin receptor 2
  • Cyclic AMP