Abstract
Hemorrhage is the major complication of IV recombinant tissue plasminogen activator (rt-PA) treatment for stroke. We report three patients with mild or indistinct cardiac symptoms prior to thrombolysis in whom hemodynamically significant cardiac tamponade occurred after treatment with rt-PA. Acute ischemic stroke patients may have undetected myocardial or pericardial disease that may pose a risk for hemopericardium and life-threatening tamponade after treatment with rt-PA.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Brain Ischemia / drug therapy*
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Cardiac Tamponade / chemically induced*
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Cardiac Tamponade / diagnostic imaging
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Cerebrovascular Disorders / drug therapy*
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Fatal Outcome
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Female
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Humans
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Middle Aged
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Pericardial Effusion / chemically induced*
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Pericardial Effusion / diagnostic imaging
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Plasminogen Activators / adverse effects*
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Plasminogen Activators / therapeutic use
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Recombinant Proteins
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Thrombolytic Therapy / adverse effects*
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Tissue Plasminogen Activator / adverse effects*
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Tissue Plasminogen Activator / therapeutic use
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Ultrasonography
Substances
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Recombinant Proteins
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Plasminogen Activators
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Tissue Plasminogen Activator