Abstract
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromosome Mapping
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Chromosomes, Bacterial
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Drug Resistance, Microbial
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Genome, Bacterial*
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Humans
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Lipid Metabolism
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Molecular Sequence Data
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / metabolism
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Mycobacterium tuberculosis / pathogenicity
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Sequence Analysis, DNA
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Tuberculosis / microbiology
Associated data
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GENBANK/AL008687
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GENBANK/AL008883
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GENBANK/AL008967
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GENBANK/AL009198
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GENBANK/AL010186
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GENBANK/AL021006
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GENBANK/AL021070
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GENBANK/AL021184
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GENBANK/AL021185
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GENBANK/AL021186
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GENBANK/AL021246
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GENBANK/AL021287
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GENBANK/AL021309
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GENBANK/AL021426
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GENBANK/AL021427
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GENBANK/AL021428
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GENBANK/AL021646
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GENBANK/AL021840
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GENBANK/AL021841
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GENBANK/AL021897
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GENBANK/AL021899
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GENBANK/AL021922
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GENBANK/AL021924
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GENBANK/AL021925
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GENBANK/AL021926
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GENBANK/AL021927
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GENBANK/AL021928
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GENBANK/AL021929
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GENBANK/AL021930
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GENBANK/AL021931