Abstract
The activation of B and T cells by a wide range of stimuli can rapidly induce specific gene expression via a mechanism that promotes the nuclear translocation of different Rel/nuclear factor-kappa B (NF-kappa B) transcription factors which are normally resident in the cytoplasm. Recent findings highlight the crucial roles of specific Rel/NF-kappa B family members in the processes of cell division, apoptosis and differentiation that accompany lymphocyte activation.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Apoptosis
-
Biological Transport
-
Cell Differentiation
-
Cell Division
-
Cell Nucleus / metabolism
-
Cytoplasm / metabolism
-
I-kappa B Kinase
-
Lymphocyte Activation / physiology*
-
Lymphocyte Subsets / immunology*
-
Lymphocyte Subsets / metabolism
-
Mice
-
Mice, Knockout
-
Mice, Transgenic
-
Models, Genetic
-
Models, Immunological
-
NF-kappa B / genetics
-
NF-kappa B / physiology*
-
Protein Serine-Threonine Kinases / physiology
-
Proto-Oncogene Proteins / genetics
-
Proto-Oncogene Proteins / physiology*
-
Proto-Oncogene Proteins c-rel
Substances
-
NF-kappa B
-
Proto-Oncogene Proteins
-
Proto-Oncogene Proteins c-rel
-
Protein Serine-Threonine Kinases
-
Chuk protein, mouse
-
I-kappa B Kinase
-
Ikbkb protein, mouse
-
Ikbke protein, mouse