Abstract
A second isoform of pT alpha, "pT alpha(b)," is derived from the pT alpha locus by tissue-specific, alternative splicing. pT alpha(b) is coexpressed in the thymus with the previously characterized form of pT alpha (which we term pT alpha(a)) and is also expressed in peripheral cells without pT alpha(a). While pT alpha(a) acts to retain most TCR beta-chains intracellularly, pT alpha(b) permits higher levels of cell surface TCR beta expression and facilitates signaling from a CD3-TCR beta complex.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing
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Animals
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Cell Separation
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Clone Cells
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Isomerism
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Lymphocyte Activation / genetics
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Membrane Glycoproteins / biosynthesis*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / physiology*
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Mice
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Mice, Knockout
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RNA, Messenger / biosynthesis
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Receptors, Antigen, T-Cell, alpha-beta / biosynthesis*
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / physiology*
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Signal Transduction / genetics
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Signal Transduction / immunology
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
Substances
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Membrane Glycoproteins
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RNA, Messenger
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Receptors, Antigen, T-Cell, alpha-beta
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pre-T cell receptor alpha